LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer
Ray Pillai, Ali Rashidfarrokhi, Yuan Hao, Warren L. Wu, Mariana C.S. Mancini, Burcu Karadal-Ferrena, Sofia G. Dimitriadoy, Michael Cross, Anna H. Yeaton, Shih Ming Huang, Arjun Bhutkar, Alberto M. Herrera, Sahith Rajalingam, Makiko Hayashi, Kuan-lin Huang, Eric Bartnicki, Anastasia-Maria Zavitsanou, Ellie Ivanova, Corrin Wohlhieter, Sarah E. LeBoeuf, Ting Chen, Cynthia A. Loomis, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw Aleksander Smolen, Jun-Chieh J. Tsay, Fernando Moreira Simabuco, Charles M. Rudin, Andre L. Moreira, Kamal M. Khanna, Harvey I. Pass, Kwok-Kin Wong, Shohei Koide, Aristotelis Tsirigos, Sergei B. Koralov, Thales Papagiannakopoulos
Cancer Discovery. 2026 April 20, https://doi.org/10.1158/2159-8290.CD-25-0470
The integrated stress response promotes immune evasion through lipocalin 2
Bossowski JP, Pillai R, Kilian J, Wong Lau A, Nakamura M, Rashidfarrokhi A,
Hao Y, Li R, Wu K, Hattori T, Glasser E, Koide A, Wang L, Moreira AL, Hajdu C, Rajalingam S, LeBoeuf SE, Le H, Lee S, Oh JW, Joe C, Kim H, Ock CY, Lee SH, Wang H, Patel AAH, Sayin VI, Tsirigos A, Wong KK, Koralov SB, Pende M, Sánchez-Rivera FJ, Simeone DM, Zervantonakis IK, Koide S, Papagiannakopoulos T.
Nature. 2026 Feb 18. doi: 10.1038/s41586-026-10143-0.
Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
Ciampricotti M, Karakousi T, Richards AL, Quintanal-Villalonga À, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, Ventura A, Rideout WM 3rd, Akama-Garren EH, Jacks T, Donoghue MTA, Sen T, Oliver TG, Poirier JT, Papagiannakopoulos T #, Rudin CM#.
# Co-corresponding author
Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T.
Sci Adv. 2021 Nov 19;7(47):eabk1023. doi: 10.1126/sciadv.abk1023. Epub 2021 Nov 17.
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer
Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK.
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer
Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, Diolaiti D, Papagiannakopoulos TY, Lyssiotis CA, Simeone DM.
Lower Airway Dysbiosis Affects Lung Cancer Progression
Tsay JJ, Wu BG, Sulaiman I, Gershner K, Schluger R, Li Y, Yie TA, Meyn P, Olsen E, Perez L, Franca B, Carpenito J, Iizumi T, El-Ashmawy M, Badri M, Morton JT, Shen N, He L, Michaud G, Rafeq S, Bessich JL, Smith RL, Sauthoff H, Felner K, Pillai R, Zavitsanou AM, Koralov SB, Mezzano V, Loomis CA, Moreira AL, Moore W, Tsirigos A, Heguy A, Rom WN, Sterman DH, Pass HI, Clemente JC, Li H, Bonneau R, Wong KK, Papagiannakopoulos T, Segal LN.
Cancer Discov. 2021 Feb;11(2):293-307. doi: 10.1158/2159-8290.CD-20-0263. Epub 2020 Nov 11.
In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma
Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, Khodadadi-Jamayran A, Wang W, Chen T, Deng J, Ranieri M, Fang Z, Pyon V, Dowling CM, Bagdatlioglu E, Almonte C, Labbe K, Silver H, Rabin AR, Jani K, Tsirigos A, Papagiannakopoulos T, Hammerman PS, Velcheti V, Freeman GJ, Qi J, Miller G, Wong KK.
Cancer Discov. 2020 Feb;10(2):270-287. doi: 10.1158/2159-8290.CD-19-0780. Epub 2019 Nov 19.
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR.
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2232-2236. doi: 10.1073/pnas.1814102116. Epub 2019 Jan 23. PubMed PMID: 30674677; PubMed Central PMCID: PMC6369805.
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
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Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.
# Co-corresponding author
*First Co-Author
Application of CRISPR-mediated genome engineering in cancer research
Sayin VI, Papagiannakopoulos T.
Cancer Lett. 2016 Mar 18. pii: S0304-3835(16)30179-3. doi: 10.1016/j.canlet.2016.03.029. [Epub ahead of print] PMID: 27000990
Rapid modeling of cooperating genetic events in cancer through somatic genome editing
Sánchez-Rivera, F. J. *; Papagiannakopoulos, T.*; Romero, R.; Tammela, T.; Bauer, M. R.; Bhutkar, A.; Joshi, N.S.; Subbaraj, L.; Bronson, R. T.; Xue, X.; Jacks, T.
Nature. (2014), doi:10.1038/nature13906
*First Co-Author
CRISPR-mediated direct mutation of cancer genes in the mouse liver
Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N. S., Cai, W., Yang, G., Bronson, R., Crowley, D. G., Zhang, F., Anderson, D. G., Sharp, P. A. & Jacks, T.
Nature, doi:10.1038/nature13589 (2014).
Genetic and clonal dissection of murine small cell lung cancer progression by genome sequencing
McFadden DG*, Papagiannakopoulos T.*, Taylor-Weiner A*, Stewart C*, Carter SL*, Cibulskis K, Bhutkar A , McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. (2013)
Cell 156, 1298-1311, doi:10.1016/j.cell.2014.02.031 (2014).
*First Co-Authors