CRISPR/Mouse Models of Cancer, Tumor Immunology Thales Papagiannakopoulos CRISPR/Mouse Models of Cancer, Tumor Immunology Thales Papagiannakopoulos

LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer

Ray Pillai, Ali Rashidfarrokhi, Yuan Hao, Warren L. Wu, Mariana C.S. Mancini, Burcu Karadal-Ferrena, Sofia G. Dimitriadoy, Michael Cross, Anna H. Yeaton, Shih Ming Huang, Arjun Bhutkar, Alberto M. Herrera, Sahith Rajalingam, Makiko Hayashi, Kuan-lin Huang, Eric Bartnicki, Anastasia-Maria Zavitsanou, Ellie Ivanova, Corrin Wohlhieter, Sarah E. LeBoeuf, Ting Chen, Cynthia A. Loomis, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw Aleksander Smolen, Jun-Chieh J. Tsay, Fernando Moreira Simabuco, Charles M. Rudin, Andre L. Moreira, Kamal M. Khanna, Harvey I. Pass, Kwok-Kin Wong, Shohei Koide, Aristotelis Tsirigos, Sergei B. Koralov, Thales Papagiannakopoulos

Cancer Discovery. 2026 April 20, https://doi.org/10.1158/2159-8290.CD-25-0470

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The integrated stress response promotes immune evasion through lipocalin 2

Bossowski JP, Pillai R, Kilian J, Wong Lau A, Nakamura M, Rashidfarrokhi A,

Hao Y, Li R, Wu K, Hattori T, Glasser E, Koide A, Wang L, Moreira AL, Hajdu C, Rajalingam S, LeBoeuf SE, Le H, Lee S, Oh JW, Joe C, Kim H, Ock CY, Lee SH, Wang H, Patel AAH, Sayin VI, Tsirigos A, Wong KK, Koralov SB, Pende M, Sánchez-Rivera FJ, Simeone DM, Zervantonakis IK, Koide S, Papagiannakopoulos T.

Nature. 2026 Feb 18. doi: 10.1038/s41586-026-10143-0.

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Cancer Metabolism, Tumor Immunology Thales Papagiannakopoulos Cancer Metabolism, Tumor Immunology Thales Papagiannakopoulos

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T.

Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859. Epub 2024 Mar 27. PMID:38536921

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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK.

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Lower Airway Dysbiosis Affects Lung Cancer Progression

Tsay JJ, Wu BG, Sulaiman I, Gershner K, Schluger R, Li Y, Yie TA, Meyn P, Olsen E, Perez L, Franca B, Carpenito J, Iizumi T, El-Ashmawy M, Badri M, Morton JT, Shen N, He L, Michaud G, Rafeq S, Bessich JL, Smith RL, Sauthoff H, Felner K, Pillai R, Zavitsanou AM, Koralov SB, Mezzano V, Loomis CA, Moreira AL, Moore W, Tsirigos A, Heguy A, Rom WN, Sterman DH, Pass HI, Clemente JC, Li H, Bonneau R, Wong KK, Papagiannakopoulos T, Segal LN.

Cancer Discov. 2021 Feb;11(2):293-307. doi: 10.1158/2159-8290.CD-20-0263. Epub 2020 Nov 11.

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