Metabolic features of cancer cells in NRF2 addiction status
Okazaki K, Papagiannakopoulos T, Motohashi H.
Biophys Rev. 2020 Feb 28. doi: 10.1007/s12551-020-00659-8. [Epub ahead of print] Review.
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T.
Cell Metab. 2020 Feb 4;31(2):339-350.e4. doi: 10.1016/j.cmet.2019.11.012. Epub 2019 Dec 5.
In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma
Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, Khodadadi-Jamayran A, Wang W, Chen T, Deng J, Ranieri M, Fang Z, Pyon V, Dowling CM, Bagdatlioglu E, Almonte C, Labbe K, Silver H, Rabin AR, Jani K, Tsirigos A, Papagiannakopoulos T, Hammerman PS, Velcheti V, Freeman GJ, Qi J, Miller G, Wong KK.
Cancer Discov. 2020 Feb;10(2):270-287. doi: 10.1158/2159-8290.CD-19-0780. Epub 2019 Nov 19.
Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
Lignitto L., LeBoeuf S., Homer H., Jiang S., Askenazi M., Karakousi T., Pass H., Bhutkar A., Tsirigos A., Ueberheide B., Sayin V., Papagiannakopoulos #T, and Pagano M#. Cell online, 2019.
# Co-corresponding author
Targeting Metabolic Bottlenecks in Lung Cancer
Sayin VI, LeBoeuf SE, Papagiannakopoulos T.
Trends Cancer. 2019 Aug;5(8):457-459. doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE.
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. doi: 10.1073/pnas.1903244116. Epub 2019 May 16. PubMed PMID: 31097586; PubMed Central PMCID: PMC6561278.
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR.
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2232-2236. doi: 10.1073/pnas.1814102116. Epub 2019 Jan 23. PubMed PMID: 30674677; PubMed Central PMCID: PMC6369805.
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
Snuderl M, Kannan K, Pfaff E, Wang S, Stafford JM, Serrano J, Heguy A, Ray K, Faustin A, Aminova O, Dolgalev I, Stapleton SL, Zagzag D, Chiriboga L, Gardner SL, Wisoff JH, Golfinos JG, Capper D, Hovestadt V, Rosenblum MK, Placantonakis DG, LeBoeuf SE, Papagiannakopoulos TY, Chavez L, Ahsan S, Eberhart CG, Pfister SM, Jones DTW, Karajannis MA.
Nat Commun. 2018 Jul 20;9(1):2868. doi: 10.1038/s41467-018-05029-3. PubMed PMID: 30030436; PubMed Central PMCID: PMC6054684.
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.
Nature cell biology. 2018; 20(7):775-781. NIHMSID: NIHMS966847. PubMed [journal]PMID: 29941933 PMCID: PMC6030478
Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice
Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT.
PloS one. 2018; 13(5):e0198139. PubMed [journal]PMID: 29799837 PMCID: PMC5969769
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.
Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.
Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Sayin VI*, LeBoeuf SE*, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.
Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.
*First Co-Author
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T #, Papagiannakopoulos T #.
Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.
# Co-corresponding author
*First Co-Author
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key driver mutational events
Ashouri, A.*; Sayin, V.I.*; Van den Eynden, J.; Papagiannakopoulos, T.#; Larsson E. #
Nature Communications. (2016).
# Co-corresponding author *First Co-Author
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.
Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.
Circadian Rhythm Disruption Promotes Lung Tumorigenesis
Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.
Cell Metabolism. 2016. Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28. PMID: 27476975
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis
Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.
Cell. 2016; 165(4):896-909. PubMed [journal] PMID: 27153497
Application of CRISPR-mediated genome engineering in cancer research
Sayin VI, Papagiannakopoulos T.
Cancer Lett. 2016 Mar 18. pii: S0304-3835(16)30179-3. doi: 10.1016/j.canlet.2016.03.029. [Epub ahead of print] PMID: 27000990
A Modular Assembly Platform for Rapid Generation of DNA Constructs
Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T.
Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836.