Systemic Metabolism and Cancer Thales Papagiannakopoulos Systemic Metabolism and Cancer Thales Papagiannakopoulos

A dietary switch promotes sensory neuron–dependent cancer-associated cachexia

Cross M, Kotschi S, Wu W, Luciano-Mateo F, Kwon YY, Dantas E, Niazi T, Chen S, Rashidfarrokhi A, Pillai R, Sanford J, Kim J, Hsiang J, Gamallo-Lana B, Mar AC, Hao Y, Rajalingam S, Huang A, Shan J, Issa HA, Gomez M, Wang AR, Zhao X, Janowitz T, White E, Liu Y, Wong KK, Segal LN, Hui S, Goncalves MD, Froemke RC, Papagiannakopoulos T.

Science. 2026 Jul 2;393(6806):90-97. doi: 10.1126/science.adz4196. Epub 2026 Jul 2. PMID: 42391376.

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CRISPR/Mouse Models of Cancer, Tumor Immunology Thales Papagiannakopoulos CRISPR/Mouse Models of Cancer, Tumor Immunology Thales Papagiannakopoulos

LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer

Ray Pillai, Ali Rashidfarrokhi, Yuan Hao, Warren L. Wu, Mariana C.S. Mancini, Burcu Karadal-Ferrena, Sofia G. Dimitriadoy, Michael Cross, Anna H. Yeaton, Shih Ming Huang, Arjun Bhutkar, Alberto M. Herrera, Sahith Rajalingam, Makiko Hayashi, Kuan-lin Huang, Eric Bartnicki, Anastasia-Maria Zavitsanou, Ellie Ivanova, Corrin Wohlhieter, Sarah E. LeBoeuf, Ting Chen, Cynthia A. Loomis, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw Aleksander Smolen, Jun-Chieh J. Tsay, Fernando Moreira Simabuco, Charles M. Rudin, Andre L. Moreira, Kamal M. Khanna, Harvey I. Pass, Kwok-Kin Wong, Shohei Koide, Aristotelis Tsirigos, Sergei B. Koralov, Thales Papagiannakopoulos

Cancer Discovery. 2026 April 20, https://doi.org/10.1158/2159-8290.CD-25-0470

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The integrated stress response promotes immune evasion through lipocalin 2

Bossowski JP, Pillai R, Kilian J, Wong Lau A, Nakamura M, Rashidfarrokhi A,

Hao Y, Li R, Wu K, Hattori T, Glasser E, Koide A, Wang L, Moreira AL, Hajdu C, Rajalingam S, LeBoeuf SE, Le H, Lee S, Oh JW, Joe C, Kim H, Ock CY, Lee SH, Wang H, Patel AAH, Sayin VI, Tsirigos A, Wong KK, Koralov SB, Pende M, Sánchez-Rivera FJ, Simeone DM, Zervantonakis IK, Koide S, Papagiannakopoulos T.

Nature. 2026 Feb 18. doi: 10.1038/s41586-026-10143-0.

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Cancer Metabolism, Systemic Metabolism and Cancer Thales Papagiannakopoulos Cancer Metabolism, Systemic Metabolism and Cancer Thales Papagiannakopoulos

Unravelling cysteine-deficiency-associated rapid weight loss.

Varghese A, Gusarov I, Gamallo-Lana B, Dolgonos D, Mankan Y, Shamovsky I, Phan M, Jones R, Gomez-Jenkins M, White E, Wang R, Jones DR, Papagiannakopoulos T, Pacold ME, Mar AC, Littman DR, Nudler E.

Nature. 2025 May 21. doi: 10.1038/s41586-025-08996-y. PMID: 40399674

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Cancer Metabolism Thales Papagiannakopoulos Cancer Metabolism Thales Papagiannakopoulos

Ferroptosis in health and disease

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M.

Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. PMID:38908072

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Cancer Metabolism Thales Papagiannakopoulos Cancer Metabolism Thales Papagiannakopoulos

Cellular adaptation to cancer therapy along a resistance continuum

França GS, Baron M, King BR, Bossowski JP, Bjornberg A, Pour M, Rao A, Patel AS, Misirlioglu S, Barkley D, Tang KH, Dolgalev I, Liberman DA, Avital G, Kuperwaser F, Chiodin M, Levine DA, Papagiannakopoulos T, Marusyk A, Lionnet T, Yanai I.

Nature. 2024 Jul;631(8022):876-883. doi: 10.1038/s41586-024-07690-9. Epub 2024 Jul 10. PMID:38987605

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Cancer Metabolism, Tumor Immunology Thales Papagiannakopoulos Cancer Metabolism, Tumor Immunology Thales Papagiannakopoulos

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T.

Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859. Epub 2024 Mar 27. PMID:38536921

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Gabriel de Souza Gabriel de Souza

KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

Zavitsanou AM, Pillai R, Hao Y, Wu WL, Bartnicki E, Karakousi T, Rajalingam S, Herrera A, Karatza A, Rashidfarrokhi A, Solis S, Ciampricotti M, Yeaton AH, Ivanova E, Wohlhieter CA, Buus TB, Hayashi M, Karadal-Ferrena B, Pass HI, Poirier JT, Rudin CM, Wong KK, Moreira AL, Khanna KM, Tsirigos A, Papagiannakopoulos T, Koralov SB.

Cell Rep. 2023 Nov 28;42(11):113295. doi: 10.1016/j.celrep.2023.113295. Epub 2023 Oct 26. PMID: 37889752

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Gabriel de Souza Gabriel de Souza

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Dolgalev I, Zhou H, Murrell N, Le H, Sakellaropoulos T, Coudray N, Zhu K, Vasudevaraja V, Yeaton A, Goparaju C, Li Y, Sulaiman I, Tsay JJ, Meyn P, Mohamed H, Sydney I, Shiomi T, Ramaswami S, Narula N, Kulicke R, Davis FP, Stransky N, Smolen GA, Cheng WY, Cai J, Punekar S, Velcheti V, Sterman DH, Poirier JT, Neel B, Wong KK, Chiriboga L, Heguy A, Papagiannakopoulos T, Nadorp B, Snuderl M, Segal LN, Moreira AL, Pass HI, Tsirigos A.

Nat Commun. 2023 Nov 8;14(1):6764. doi: 10.1038/s41467-023-42327-x. PMID: 37938580

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Gabriel de Souza Gabriel de Souza

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

Rashidfarrokhi A, Pillai R, Hao Y, Wu WL, Karadal-Ferrena B, Dimitriadoy SG, Cross M, Yeaton AH, Huang SM, Bhutkar AJ, Herrera A, Rajalingam S, Hayashi M, Huang KL, Bartnicki E, Zavitsanou AM, Wohlhieter CA, Leboeuf SE, Chen T, Loomis C, Mezzano V, Kulicke R, Davis FP, Stransky N, Smolen GA, Rudin CM, Moreira AL, Khanna KM, Pass HI, Wong KK, Koide S, Tsirigos A, Koralov SB, Papagiannakopoulos T.

bioRxiv. 2023 Jul 17:2023.07.15.549147. doi: 10.1101/2023.07.15.549147. Preprint. PMID: 37502974

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Gabriel de Souza Gabriel de Souza

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T.

bioRxiv. 2023 Jun 28:2023.06.27.546750. doi: 10.1101/2023.06.27.546750. Preprint. PMID: 37425844

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