SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity
Zhong H, Lu W, Tang Y, Wiel C, Wei Y, Cao J, Riedlinger G, Papagiannakopoulos T, Guo JY, Bergo MO, Kang Y, Ganesan S, Sabaawy HE, Pine SR.
Oncogene. 2023 Jun;42(27):2183-2194. doi: 10.1038/s41388-023-02715-5. Epub 2023 May 31. PMID: 37258742
Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors
Karagiannis D, Wu W, Li A, Hayashi M, Chen X, Yip M, Mangipudy V, Xu X, Sánchez-Rivera FJ, Soto-Feliciano YM, Ye J, Papagiannakopoulos T, Lu C.
bioRxiv. 2023 Apr 28:2023.04.24.538118. doi: 10.1101/2023.04.24.538118. Preprint. PMID: 37162970
In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer
Deng J, Peng DH, Fenyo D, Yuan H, Lopez A, Levin DS, Meynardie M, Quinteros M, Ranieri M, Sahu S, Lau SCM, Shum E, Velcheti V, Punekar SR, Rekhtman N, Dowling CM, Weerasekara V, Xue Y, Ji H, Siu Y, Jones D, Hata AN, Shimamura T, Poirier JT, Rudin CM, Hattori T, Koide S, Papagiannakopoulos T, Neel BG, Bardeesy N, Wong KK.
bioRxiv. 2023 Apr 20:2023.04.18.537350. doi: 10.1101/2023.04.18.537350. Preprint. PMID: 37131623
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Cell Metab. 2023 Apr 4;35(4):722. doi: 10.1016/j.cmet.2023.03.011. PMID: 37019082
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Cell Metab. 2023 Mar 7;35(3):487-503.e7. doi: 10.1016/j.cmet.2023.01.012. Epub 2023 Feb 24. PMID: 36841242
DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome
Guidry K, Vasudevaraja V, Labbe K, Mohamed H, Serrano J, Guidry BW, DeLorenzo M, Zhang H, Deng J, Sahu S, Almonte C, Moreira AL, Tsirigos A, Papagiannakopoulos T, Pass H, Snuderl M, Wong KK.
Clin Cancer Res. 2022 Sep 1;28(17):3824-3835. doi: 10.1158/1078-0432.CCR-22-0391. PMID: 35802677
NRF2: KEAPing Tumors Protected
Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T.
Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. PMID: 35101864
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
Marzio A, Kurz E, Sahni JM, Di Feo G, Puccini J, Jiang S, Hirsch CA, Arbini AA, Wu WL, Pass HI, Bar-Sagi D, Papagiannakopoulos T, Pagano M.
Cell. 2022 Jan 6;185(1):169-183.e19. doi: 10.1016/j.cell.2021.12.005. Epub 2021 Dec 27. PMID: 34963055
Valine tRNA levels and availability regulate complex I assembly in leukaemia
Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I.
Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22.
Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
Ciampricotti M, Karakousi T, Richards AL, Quintanal-Villalonga À, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, Ventura A, Rideout WM 3rd, Akama-Garren EH, Jacks T, Donoghue MTA, Sen T, Oliver TG, Poirier JT, Papagiannakopoulos T #, Rudin CM#.
# Co-corresponding author
Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T.
Sci Adv. 2021 Nov 19;7(47):eabk1023. doi: 10.1126/sciadv.abk1023. Epub 2021 Nov 17.
Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment
Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA.
Nat Rev Cancer. 2021 Aug;21(8):510-525. doi: 10.1038/s41568-021-00375-9. Epub 2021 Jul 9.
Hunger brings down the tumor fort
Zavitsanou AM, Papagiannakopoulos T.
Trends Cell Biol. 2021 Aug;31(8):616-617. doi: 10.1016/j.tcb.2021.05.005. Epub 2021 May 22.
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer
Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK.
Improving oligo-conjugated antibody signal in multimodal single-cell analysis
Buus TB, Herrera A, Ivanova E, Mimitou E, Cheng A, Herati RS, Papagiannakopoulos T, Smibert P, Odum N, Koralov SB.
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer
Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, Diolaiti D, Papagiannakopoulos TY, Lyssiotis CA, Simeone DM.
The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension
Wu WL, Papagiannakopoulos T.
Mol Cell. 2020 Dec 3;80(5):760-761. doi: 10.1016/j.molcel.2020.11.022.
Lower Airway Dysbiosis Affects Lung Cancer Progression
Tsay JJ, Wu BG, Sulaiman I, Gershner K, Schluger R, Li Y, Yie TA, Meyn P, Olsen E, Perez L, Franca B, Carpenito J, Iizumi T, El-Ashmawy M, Badri M, Morton JT, Shen N, He L, Michaud G, Rafeq S, Bessich JL, Smith RL, Sauthoff H, Felner K, Pillai R, Zavitsanou AM, Koralov SB, Mezzano V, Loomis CA, Moreira AL, Moore W, Tsirigos A, Heguy A, Rom WN, Sterman DH, Pass HI, Clemente JC, Li H, Bonneau R, Wong KK, Papagiannakopoulos T, Segal LN.
Cancer Discov. 2021 Feb;11(2):293-307. doi: 10.1158/2159-8290.CD-20-0263. Epub 2020 Nov 11.
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
Wu L, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos T, Kimmelman AC, Satija R, Littman DR.
Cell. 2020 Aug 6;182(3):641-654.e20. doi: 10.1016/j.cell.2020.06.014. Epub 2020 Jul 1.